Solumatrix™

Reducing drug particle size to enhance drug dissolution

iCeutica’s proprietary SoluMatrix reformulation platform is a straightforward, scaleable manufacturing process that can produce nano-sized drug particles which are 10 to 200 times smaller than conventional drug particles. The particles are generated using the patented SoluMatrix dry milling methodology, which both grinds the drug particles into a superfine powder and protects those nano-particles from subsequent agglomeration (or clumping together into big particles). SoluMatrix powders are easy to formulate into tablets, capsules and a range of other dosage forms for patient administration.

Benefits

Benefits of SoluMatrix reformulation

It is estimated that approximately 10% of currently-marketed drugs and at least 40% of drugs in development have limitations due to poor water solubility. By reducing drug particle size using SoluMatrix™, the objective is to achieve a vast improvement in the dissolution properties of the relevant drugs, without changing the chemical structures of the relevant drug molecules themselves. With improved dissolution, the SoluMatrix™-reformulated drugs are expected to have a number of significant benefits, including:

• reducing the dose required to achieve a therapeutic effect; and/or

• speeding up the drug’s therapeutic effect; and/or

• removing the need to take a drug with or without food (and thereby improving patient convenience and compliance).

Range of delivery routes

The SoluMatrix reformulation platform has been utilised to create a number of different solid oral dosage forms which have been utilised in five clinical trials to date. The SoluMatrix powders have excellent flow properties and very low electrostatic charge which makes them well suited to high speed/high volume handling and filling equipment.

In addition to oral delivery routes, the SoluMatrix reformulation platform has been applied to create dosage forms for inhalable, intranasal and injectable delivery routes with success.